Cancer therapeutic resistance
WebAbstract. Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy. In the clinic, therapeutic resistance is largely attributed to tumor heterogeneity. Growing evidence indicates that cancer stem cells (CSCs) are the major source of tumor heterogeneity. WebDrug resistance in cancer comes in two forms: intrinsic resistance and acquired resistance. Intrinsic resistance is present before a therapy is administered, and it …
Cancer therapeutic resistance
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WebApr 5, 2024 · Cancer therapeutic resistance occurs as cancers develop resistance to treatments such as chemotherapy, radiotherapy and targeted therapies, through many … Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options. Researchers at ...
WebAug 6, 2024 · At present, the biggest problem facing cancer immunotherapy is to deeply dissect its complex drug resistance mechanisms and adopt effective combination therapy strategies to overcome it. The … WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using …
WebProstate cancer is the second leading cause of cancer deaths in the USA. The challenge in managing castration-resistant prostate cancer (CRPC) stems not from the lack of therapeutic options but from the limited duration of clinical and survival benefit offered by treatments in this setting due to primary and acquired resistance. WebSep 2, 2024 · Role for salinomycin in overcoming breast cancer therapeutic resistance. Breast cancer cells undergoing EMT or those associated with stem-like states are frequently resistant to standard-of-care breast cancer therapies. Salinomycin has shown clinical utility in selectively targeting chemoresistant, mesenchymal BCSCs. However, breast cancer ...
WebApr 14, 2024 · Sphingosine kinase 1 is a protooncogene associated with therapeutic resistance in breast cancer [164,165] and can be inhibited with the synthetic structural analog of sphingosine, Fingolimod (FTY720) [166,167]. Interestingly, FTY720 inhibits autophagy and triggers apoptosis in trastuzumab-resistant breast cancer cells .
WebApr 14, 2024 · Sphingosine kinase 1 is a protooncogene associated with therapeutic resistance in breast cancer [164,165] and can be inhibited with the synthetic structural … sondheim clownsWebApr 10, 2024 · Although the connection between NET formation and radiation therapy resistance in malignant tumors has been reported, whether NETosis could be induced by chemotherapy and contribute to chemotherapeutic response remains unclear. In this issue of Cancer Cell, Mousset et al. uncover a “chemoNETosis pathway,” in which … sondheim concert 90WebTherapeutic resistance is a process which is unpredictable and difficult to model. Therefore, better tools are needed to identify or predict resistance mechanisms. This … sondheim concert 2022WebTherapeutic Resistance in Cancer. Editors of the AACR Journals reviewed recently published content to identify hot topics across the entire portfolio. This collection focuses … sondheim creditsWeb2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … small digital thermometer hikingWebAbstract. Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy. In the clinic, therapeutic resistance is largely attributed to tumor heterogeneity. Growing … sondheim collaborator west side storyWebIn the last decades, cancer therapies have substantially improved cancer care and patients’ survival. The introduction of targeted therapies had a major impact on the management of cancer. However, millions of people still die from cancer every year and cancer drug resistance remains the Achilles' heel of cancer chemotherapeutics. small digital thermometer indoor