Ethylcamptothecin
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine. It has been used clinically more recently in China for the tr… WebCamptothecin (NSC-100880, CPT, Campathecin, (S)- (+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. …
Ethylcamptothecin
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WebShowing 1-3 of 3 results for " 78287-27-1 " within Products Sort by Relevance. Irinotecan Related Compound E Web7-Ethylcamptothecin. Others Cancer; 7-Ethylcamptothecin is one of camptothecin analogues. camptothecin (CPT), a cytotoxic alkaloid isolated from Camptotheca …
Web苏州爱玛特生物科技有限公司 公司信息 WebApr 15, 2005 · A series of new camptothecin derivatives, as topoisomerase I inhibitor, were synthesized to identify potent antitumor agents. The synthesis method was based on the Claisen rearrangement of 10-allyloxy-7-ethylcamptothecin. All of the compounds were assayed for cytotoxicity against two human tumor cel …
WebDescription: 7-Ethylcamptothecin has the superior antitumor activity than camptothecin, it has a stronger growth-inhibiting activity against tumor cells and remains in the intestinal tract for a longer time and in higher amounts when administered in vivo. In vivo: Cancer Treat Rep. 1987 Apr;71 (4):341-8. Action of 7-ethylcamptothecin on tumor ... Web7-Ethylcamptothecin quantity. Add to cart. 50 mg: $765: 7-Ethylcamptothecin quantity. Add to cart. 100 mg: $1146: 7-Ethylcamptothecin quantity. Add to cart. Bulk inquiry. Inquire about bulk pricing for large orders! Bulk Inquiry.
WebFeb 1, 2004 · Abstract. Despite the high antitumor activity of camptothecins, few derivatives have been developed and tested for human treatment of solid tumors, due to unpredictable toxicity mainly connected to their poor water solubility. We report the conjugation of the antitumor agent 10-amino-7-hydroxy camptothecin (SN-392) to linear or branched poly ...
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