Phosphotyrosine binding domain
WebPhosphorylation may be viewed as a device to control the assembly of protein complexes, and thereby to regulate the dynamic behavior of the cell. Phospho-dependent interaction …
Phosphotyrosine binding domain
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WebThe F3 subdomain is a sandwich of two orthogonal antiparallel β sheets followed by an α helix; this fold is found in a number of structures, including the phosphotyrosine-binding (PTB) 1 and pleckstrin homology domains. In this study, we have localized a principal integrin β tail-binding site of talin to the predicted 96-residue PTB-like ... WebFeb 3, 2005 · The C2 domain of PKCdelta is a phosphotyrosine binding domain. In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a …
WebOct 6, 2006 · The RET receptor tyrosine kinase is important for several different biological functions during development. The recruitment at the phosphorylated Tyr1062 site in RET of a number of different … WebMar 5, 2024 · Conserved Domains (3) summary cd07631 Location: 20 → 234 BAR_APPL1; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1 cd13158 Location: 490 → 625
WebMar 29, 2024 · The PI/PTB domains differ from Src homology 2 (SH2) domains in that their binding specificity is determined by residues that lie amino terminal and not carboxy terminal to the phosphotyrosine. Recently, it has been appreciated that other cytoplasmic proteins also contain PI domains. WebApr 10, 1998 · Numb is a phosphotyrosine-binding (PTB) domain-containing protein implicated in the control of cell fate decisions during development. A modified two-hybrid screen in yeast was used to identify ...
WebFeb 26, 2003 · These motifs are part of a canonical recognition sequence for phosphotyrosine-binding (PTB) domains, protein modules that are present in a wide …
WebOct 1, 1999 · Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine … culinary institute restaurants hyde park nyWebSeveral other PI domains have been identified that may also have binding specificity for the NPXY motif. The terminology used at present to define these domains is unclear. The … easter scenes picturesWebMar 1, 2002 · Phosphotyrosine-binding (PTB) domains — also called phosphotyrosine-interacting domains ( PIDs) — were first identified in the SH2-domain-containing adaptor … easter scene illustrationWebSH2 domains bind their ligands as an extended strand; they all recognize phosphotyrosine, through a conserved, basic binding pocket, and also bind at least three residues immediately C-terminal to the phosphotyrosine, in a fashion that differs from one SH2 domain to another and provides an element of specificity in signal transduction. easter scenes imagesWebJun 11, 2014 · Hakai acts through its phosphotyrosine-binding (HYB) domain, which bears a dimeric fold that recognizes the phosphotyrosine motifs of E-cadherin, cortactin, DOK1, … easter scenery picturesWebApr 22, 2005 · Here we show that the C2 domain of PKCδ is a phosphotyrosine binding domain. We determine its specificity by peptide library screens, its affinity by isothermal titration calorimetry, and the structural basis for phosphotyrosine binding by X-ray diffraction of its crystal structure. easter scented candlesWebMar 29, 2024 · The phosphotyrosine interaction (PI) domains (also known as the PTB, or phosphotyrosine binding, domains) of Shc and IRS-1 are recently described domains that … culinary internships paid